Challenges in evaluating thromboembolic risk in acute leukemia: clinical profiling and limitations of current scoring systems.

ABSTRACT:

Background

Limited evidence is available on risk factors for thrombotic events in newly diagnosed acute leukemia (AL) patients, and predictive tools in this population need further validation.

Objectives

To evaluate the incidence of thrombosis in newly diagnosed AL patients and to validate known predictive scores.

Methods

We retrospectively included 421 patients between 2009 and 2022. Data on thrombotic events (venous and arterial) were collected from admission to 60 days of follow-up. The Khorana, International Society on Thrombosis and Haemostasis (ISTH) disseminated intravascular coagulation, and Siriraj Acute Myeloid/Lymphoblastic Leukemia scores were applied to the cohort.

Results

The cumulative incidence of thrombotic events within 60 days was 15.8%, bein

SUBMITTER: Carvalho LV 

PROVIDER: S-EPMC12455106 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature