Tumor necrosis facilitates perihilar cholangiocarcinoma metastasis by ANGPTL6-augmented vessel permeability and tumor dissemination.

ABSTRACT:

Background & aims

Tumor necrosis is a pathological feature of solid tumors that is associated with poor prognosis and aggressive characteristics. However, its prognostic significance and underlying mechanisms in perihilar cholangiocarcinoma (pCCA) remain unclear. This study aimed to investigate the prognostic impact, clinic-pathological relevance, molecular regulation, and microenvironment alterations associated with tumor necrosis in pCCA.

Methods

We recruited 306 eligible patients with pCCA to assess the prognostic impact and clinic-pathological relevance of pathological tumor necrosis. Laser capture microdissection coupled with high-resolution mass spectrometry was used to identify the molecular changes in pCCA cells within peri-necrotic regions. Single-cell RNA sequencin

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12455108 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature