Optical coherence tomography as a potential biomarker for the logopenic variant of primary progressive aphasia: A cross-sectional prospective study.

ABSTRACT:

Background

Optical coherence tomography (OCT) and OCT angiography (OCT-A) have been studied as biomarkers for Alzheimer's disease (AD), with promising results. Nevertheless, their potential in the logopenic variant of primary progressive aphasia (lvPPA), which shares the same amyloid pathology, has not yet been explored. This work aimed to characterize retinal changes in lvPPA compared to healthy controls.

Methods

Ten participants with lvPPA and eleven controls underwent OCT and OCT-A imaging. Amyloid pathology in lvPPA was confirmed by lumbar puncture. Retinal parameters included retinal nerve fiber layer (RNFL) thickness and foveal avascular zone (FAZ).

Results

Compared to controls, lvPPA participants exhibited reduced RNFL thickness in the temporal sector (p

SUBMITTER: Wu F 

PROVIDER: S-EPMC12455141 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature