Differences in Endoscopic Features of Gastric Neuroendocrine Tumor and Neuroendocrine Carcinoma From a Clinicopathological Perspective.

ABSTRACT: Gastric neuroendocrine neoplasms are a rare type of stomach cancer, classified into well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Gastric NETs (G-NETs) originate from endocrine progenitor cells in the basal layer of the mucosa, primarily in the setting of chronic atrophic gastritis, such as autoimmune gastritis. They generally exhibit low malignancy and a favorable prognosis. By contrast, gastric NECs (G-NECs), a rare subtype of gastric cancers, arise from endocrine precursor cell clones that dedifferentiate in the deep portion of pre-existing differentiated-type adenocarcinomas. G-NECs are characterized by rapid growth, frequent lymphovascular invasion, high metastatic potential, and aggressive biological behavior. Most G-NEC

SUBMITTER: Matsueda K 

PROVIDER: S-EPMC12455147 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature