Assessment of the relationship between gut microbiota, inflammatory markers, and colorectal cancer.

ABSTRACT:

Objective

This study aims to evaluate the correlation between inflammation and gut microbiota characteristics in patients with colorectal cancer (CRC) through a retrospective study.

Methods

This cross-sectional, non-interventional study included a total of 200 subjects, of which 150 were colorectal cancer (CRC) patients and 50 were healthy individuals. The study retrospectively reviewed hospital and laboratory archives and records from 2015 to 2020. Gut microbiota was analyzed using 16S rRNA sequencing. Inflammatory markers, including C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interleukin-beta (IL-1β), were measured using enzyme-linked immunosorbent assay (ELISA). Logistic regression analysis was used to evaluate the relationship

SUBMITTER: Cui Y 

PROVIDER: S-EPMC12455238 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature