Impact and Cost-effectiveness of Regular Self-digital Anorectal Examination on Syphilis Among Gay, Bisexual, and Other Men Who Have Sex With Men: A Mathematical Modeling Study.

ABSTRACT:

Background

Rising syphilis incidence among Australian gay, bisexual, and other men who have sex with men (GBMSM) requires new early detection strategies. Regular self-digital anorectal examination (self-DARE) may facilitate syphilis identification, potentially reducing transmission. We evaluated its population-level impact and cost-effectiveness in controlling syphilis among Australian GBMSM.

Methods

We developed an integrated transmission-dynamic and health-economic model, calibrated with 2012-2022 Australian GBMSM data. Over a 10-year period (2025-2034), we compared the base case with two scenarios: recommending self-DARE to men with higher sexual activity ("only high group") or to all individuals ("both groups"). We assessed changes in incidence, incremental cost-effectiv

SUBMITTER: Lai H 

PROVIDER: S-EPMC12455306 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature