Impact of Population Immunity and Public Health Measures on the Transmission of Omicron Subvariants BA.2 and BA.5 in Hong Kong.

ABSTRACT:

Background

The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and population-level vaccine administration have significantly shifted the population immunity. In Hong Kong, these shifts, coupled with the emergence of Omicron BA.5 with a strong ability of immune evasion, necessitate a deeper understanding of how population immunity and public health and social measures (PHSMs) have shaped the epidemic dynamics across age groups within the population.

Methods

We developed an age-structured, multistrain model and estimated key parameters including transmissibility for the emerging BA.5, the effects of PHSMs on transmission, and contributions of natural infection and vaccination to age-specific immunity against infection of each subvariant over ti

SUBMITTER: Wang C 

PROVIDER: S-EPMC12455309 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature