Prenatal Persistent Exposure to Organophosphate Esters and Early Childhood Brain Development: A Longitudinal Analysis.

ABSTRACT: Previous studies on the prenatal organophosphate ester (OPE) exposure's effect on children's neurodevelopment have yielded inconsistent results. In this study, we employed a longitudinal approach, capitalizing on multitime-point evaluations of exposure to OPEs and two-stage assessments of children's brain development. The study included 508 mother-child pairs. We measured seven OPEs in maternal serum throughout pregnancy and assessed children's mental health and developmental milestones at the age of 2 and 5. The group-based trajectory model identified pregnancy exposure trajectories. Generalized estimated equations and quantile-based g-computation were employed to evaluate the effects of OPEs on children's brain development. Four OPEs, including 2-ethylhexyl diphenyl phosphate (EHDPP), we

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12455345 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature