<i>APOE</i> genotype modulates the impact of sleep duration on locus coeruleus functional connectivity in pre-clinical Alzheimer's disease.

ABSTRACT: Sleep duration and Apolipoprotein E genotype are critical factors influencing Alzheimer's disease progression. This study investigates the interaction between sleep duration and Apolipoprotein E genotype on the functional connectivity of the locus coeruleus in clinically unimpaired older adults with elevated amyloid beta, a population at risk for pre-clinical Alzheimer's disease. The study included 692 clinically unimpaired older adults with elevated amyloid beta participants from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's Study (A4). Resting-state functional MRI data were analysed to construct locus coeruleus-based functional connectivity networks, and a 2 × 2 analysis of covariance was conducted to examine the main and interactive effects of sleep duration (normal versus shor

SUBMITTER: Gong L 

PROVIDER: S-EPMC12455407 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature