Evaluation of clindamycin use in bone and joint infections: is monotherapy a safe option? A monocentric observational study 2014-19.

ABSTRACT:

Background

Selecting an optimal antibiotic regimen for bone and joint infections (BJIs) is challenging due to limited high-quality evidence. Although clindamycin is widely used as an alternative treatment for susceptible microorganisms in combination therapy, its use as monotherapy is increasing. This study aimed to evaluate the efficacy and safety of clindamycin monotherapy for BJI treatment.

Methods

A monocentric observational study was conducted using data from the Reference Centre for complex BJI at our tertiary university hospital between 2014 and 2019. All adult patients with microbiologically confirmed BJI receiving clindamycin after a multidisciplinary meeting were included. Patients infected with clindamycin non-susceptible strains were excluded. Treatment failure w

SUBMITTER: Jamard S 

PROVIDER: S-EPMC12455409 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature