Risk of unprovoked seizures after discontinuation of antiseizure medication at discharge following acute symptomatic seizures.

ABSTRACT:

Objective

We aimed to investigate whether the risk of unprovoked seizures differs between patients receiving a brief antiseizure medication (ASM) course during hospitalization and those treated beyond hospital discharge following acute symptomatic seizures (ASyS).

Methods

We performed a single-center, retrospective cohort study of all consecutive adults without epilepsy who received maintenance ASM (≥48 h) after ASyS. All patients underwent continuous electroencephalographic (EEG) monitoring and were divided into those receiving ASMs only during hospitalization and those discharged on ASMs. We used propensity score matching to balance covariates between groups. Cause-specific Cox proportional hazards models analyzed the time to the first unprovoked seizure; death was treated

SUBMITTER: Punia V 

PROVIDER: S-EPMC12455424 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature