Electrochemical Deoxygenative Silylation of Alcohols.

ABSTRACT: Alcohols are highly common organic compounds but remain scarce as alkyl donors in synthetic procedures. Here, we describe an electrochemical procedure for their deoxygenative cross-electrophile coupling with hydrosilanes, furnishing organosilane products in good to excellent yields. Mechanistic studies provide insights into the operating pathways of this semi-paired electrolytic transformation, suggesting that silyl ethers are likely reaction intermediates. Furthermore, a unified mechanistic proposal is presented that accounts for observed reactivity differences with analogous deoxygenative electrocarboxylation.

SUBMITTER: Villo P 

PROVIDER: S-EPMC12455427 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature