Evaluation of potential prognostic significance of JUNB in human prostate cancer: a bioinformatic and histopathological study.

ABSTRACT:

Background

Prostate cancer is one of the most common malignancies in males worldwide. Serum prostate-specific antigen is a frequently employed biomarker in the diagnosis and risk stratification of prostate cancer; however, it is known for its low predictive accuracy for disease progression. New prognostic biomarkers are needed to distinguish aggressive prostate cancer from low-risk disease. This study aimed to identify and validate potential prognostic biomarkers of prostate cancer.

Methods

Two prostate cancer datasets from the Gene Expression Omnibus were analyzed to identify differentially expressed genes between benign prostatic hyperplasia (BPH) and prostatic carcinoma. Immunohistochemistry was used to evaluate the JUNB proto-oncogene, a subunit of the AP-1 transcription

SUBMITTER: Noufal NR 

PROVIDER: S-EPMC12455463 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature