Seizure-onset zone lateralization in temporal lobe epilepsy using 7T rs-fMRI: Direct comparison with 3T rs-fMRI.

ABSTRACT:

Objective

Resting-state functional magnetic resonance imaging (rs-fMRI) at ultra-high field strengths (≥7T) is known to provide superior signal-to-noise to comparable acquisitions at lower field strengths. In this study, we provide a direct comparison of the seizure onset-zone (SOZ) lateralizing ability of 7T rs-fMRI and 3T rs-fMRI.

Methods

We investigated a cohort of 70 patients with temporal lobe epilepsy (TLE). A paired cohort of 19 patients had 3T and 7T rs-fMRI acquisitions for direct comparison between the two field strengths. Forty-three patients had only 3T, and eight patients had only 7T rs-fMRI acquisitions. We quantified the functional connectivity between the hippocampus and other nodes within the default mode network (DMN) using seed-to-voxel connectivity, and m

SUBMITTER: Lucas A 

PROVIDER: S-EPMC12455467 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature