Bilateral Risk-Reducing Mastectomy With Immediate Breast Reconstruction Lowers Concerns of Breast Cancer in Women With a High-Risk Genetic Predisposition for Breast Cancer Compared With a Radiological Imaging Surveillance Group.

ABSTRACT:

Background and objectives

Women with a high-risk genetic predisposition for breast cancer are faced with the choice between bilateral risk-reducing mastectomy, often accompanied by immediate breast reconstruction, or radiological imaging surveillance. This study examined changes in mental well-being and health-related quality of life following surgery and compared outcomes with women adhering to surveillance. Additionally, surgical complications and regrets were assessed.

Methods

Patients were recruited from multiple clinical departments across Denmark and stratified into surgery or surveillance groups. Patient-reported outcomes were measured using validated questionnaires, including the BREAST-Q, at baseline and 3, 12, and 24 months post-surgery or post-baseline.

Results

SUBMITTER: Willert CB 

PROVIDER: S-EPMC12455535 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature