The Role of KRAS Status Among Patients Undergoing Staged Versus Simultaneous Resection for Synchronous Colorectal Liver Metastases.

ABSTRACT:

Background

This study aimed to evaluate the impact of surgical timing-simultaneous versus staged resection-on outcomes of patients with colorectal liver metastases (CRLM) in relation to KRAS mutation status, which is a key factor affecting prognosis.

Methods

Patients who underwent curative-intent resection for synchronous CRLM (sCRLM) were identified from an international, multi-institutional database. The association between clinicopathologic factors, staged versus simultaneous approach and wild-type (wtKRAS) versus mutated (mtKRAS) KRAS with long-term outcomes was assessed.

Results

Among 385 patients who underwent curative-intent resection for sCRLM, 205 (53.2%) individuals underwent a simultaneous primary tumor and CRLM resection; 180 (46.8%) individuals underwent

SUBMITTER: Baldo A 

PROVIDER: S-EPMC12455551 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature