Lateralization of Hippocampal Dentate Spikes and Sharp-Wave Ripples in Urethane Anesthetized Rats Depends on Cholinergic Tone.

ABSTRACT: Neural activity and bodily functions are inherently rhythmic and related to each other. The occurrence of hippocampal sharp-wave ripples (SPW-Rs) and dentate spikes (DSs) supporting memory consolidation is regulated by the overall state of the brain, and they also seem to aggregate to a certain phase of the breathing cycle in naturally sleeping mice. Further, SPW-Rs and DSs synchronize to a variable degree between hemispheres, but how this is affected by the neural and bodily state is unclear. Here, we recorded dorsal hippocampal local-field potentials, electrocardiogram, and respiration for several hours under urethane anesthesia in adult male Sprague-Dawley rats. For a subset of rats, we injected atropine (50 mg/kg, i.p.) halfway into the recording to decrease cholinergic and parasympath

SUBMITTER: Nokia MS 

PROVIDER: S-EPMC12455560 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature