Anti-contactin-1 autoimmune nodopathy with thymoma: case report and literature review.

ABSTRACT:

Backgrounds

Autoimmune nodopathies (ANs) with autoantibodies against cell adhesion molecules including contactin-1 (CNTN1) located in the nodes of Ranvier and paranodes have specific clinical features. Patients with anti-CNTN1 AN accompanied by paraneoplastic status have been reported. Here, we describe three patients with anti-CNTN1 AN and concurrent thymoma. In addition, we performed a literature review to investigate the relationship between demyelinating peripheral neuropathy and thymoma.

Methods

Serum CNTN1-IgG and IgG subclasses were measured by cell-based assay or enzyme-linked immunosorbent assay. Clinical, electrophysiological, and pathological data were obtained from the medical records of patients. CNTN1-IgG titers and serum neurofilament light chain (sNfL) were f

SUBMITTER: Tashiro T 

PROVIDER: S-EPMC12455620 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature