Soluble receptor for advanced glycation end product (sRAGE) levels in adolescents with obesity, insulin resistance and metabolic syndrome: A case-control study and the review of the literature.

ABSTRACT:

Objective

The aim of this study is to evaluate sRAGE levels in adolescents with obesity, and to determine the relationship between sRAGE, insulin resistance, and metabolic syndrome in a case-control study.

Methods

Thirty adolescents with insulin resistance, 28 adolescents without insulin resistance between 10 and 18 years old and 30 Healthy gender and age matched control group were included in the study. Patients with a body mass index z-score above 2, comprised the obesity group. HOMA-IR value above 3.16 was accepted as insulin resistance. Metabolic syndrome was defined based on the International Diabetes Federation definition.

Results

sRAGE levels of the both groups with obesity were lower than control and they were negative correlated with weight, body mass index,

SUBMITTER: Ustkoyuncu PS 

PROVIDER: S-EPMC12455763 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature