CoExpPhylo - a novel pipeline for biosynthesis gene discovery.

ABSTRACT:

Background

The rapid advancement of sequencing technologies has drastically increased the availability of plant genomic and transcriptomic data, shifting the challenge from data generation to functional interpretation. Identifying genes involved in specialized metabolism remains difficult. While coexpression analysis is a widely used approach to identify genes acting in the same pathway or process, it has limitations, particularly in distinguishing genes coexpressed due to shared regulatory triggers from those directly involved in the same pathway. To enhance functional predictions, integrating phylogenetic analysis provides an additional layer of confidence by considering evolutionary conservation. Here, we introduce CoExpPhylo, a computational pipeline that systematically combine

SUBMITTER: Grunig N 

PROVIDER: S-EPMC12455792 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature