Investigating causal effects of HDL-C on cognitive function through cross-sectional and Mendelian randomization analyses: concentration-response patterns and clues for Alzheimer's disease prevention.

ABSTRACT:

Background

Disrupted cholesterol homeostasis may accelerate cognitive aging. This study investigated the relationship between serum HDL-C levels and cognitive function, utilizing cross-sectional data and Mendelian randomization (MR) analysis.

Methods

A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014, including 19,931 participants. Among them, 2,777 individuals aged 60 years and older with complete HDL-C levels and cognitive function data were included. Cognitive function was assessed using tests such as the Consortium to Establish a Registry for Alzheimer's Disease Immediate and Delayed Recall, the Animal Fluency Test, and the Digit Symbol Substitution Test. Additionally, MR analysis was employed to

SUBMITTER: Fan L 

PROVIDER: S-EPMC12455801 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature