Association of high-density lipoprotein-related inflammatory indicators with diabetic foot ulcer in patients with diabetes: a population-based study.

ABSTRACT:

Background

Early identification and treatment of diabetic foot ulcer (DFU) in diabetes mellitus (DM) patients is of great importance for improving life quality. This study aimed to investigate the association between high-density lipoprotein (HDL)-related inflammatory indicators, such as neutrophils-to-HDL ratio (NHR), monocyte-to-HDL ratio (MHR), lymphocyte-to-HDL ratio (LHR), platelet-to-HDL ratio (PHR), and the occurrence of DFU in DM patients.

Methods

This study included 1211 DM patients from the National Health and Nutrition Examination Survey (1999-2004). The relationship between HDL-related inflammatory indicators and DFU was explored with logistic regression models. Using a threshold effects analysis model, the association and inflection points between HDL-related in

SUBMITTER: Deng R 

PROVIDER: S-EPMC12455812 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature