Infection and herbicide exposure implicate c-Abl kinase in α-Synuclein Ser129 phosphorylation.

ABSTRACT:

Background

Parkinson's disease is a complex, multifactorial neurodegenerative disorder characterized by aggregation of α-Synuclein into Lewy bodies, with phosphorylation at serine 129 (pSer129), serving as a key regulatory site and pathological hallmark. However, the exact mechanisms by which environmental triggers lead to this disease phenotype remain poorly understood. In this study, we investigate the impact of representative infectious and pesticide exposures on pSer129 α-Synuclein, with a particular focus on the role of cellular kinases in mediating this process.

Methods

Neuronal cells were exposed to two distinct environmental stressors: the pesticide rotenone and the well-characterized gastric bacterium Helicobacter pylori (H. pylori). Phosphorylation of Ser129 α-Synu

SUBMITTER: Ehsani M 

PROVIDER: S-EPMC12455823 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature