Cervical Spinal Cord Magnetization Transfer Ratio and Its Relationship With Clinical Outcomes in Multiple Sclerosis.

ABSTRACT:

Objective

The cervical spinal cord (cSC) is highly relevant to clinical dysfunction in multiple sclerosis (MS) but remains understudied using quantitative magnetic resonance imaging (MRI). We assessed magnetization transfer ratio (MTR), a semi-quantitative MRI measure sensitive to MS-related tissue microstructural changes, in the cSC and its relationship with clinical outcomes in radiologically isolated syndrome (RIS) and MS.

Methods

MTR data were acquired from 52 RIS, 201 relapsing-remitting MS (RRMS), 47 primary progressive MS (PPMS), and 43 control (CON) participants across four sites in the Canadian Prospective Cohort Study to Understand Progression in MS (CanProCo) using 3.0 T MRI systems. Mean MTR was compared between groups in whole cSC and sub-regions between C2-C4.

SUBMITTER: Lee LE 

PROVIDER: S-EPMC12455881 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature