Time-Frequency Fingerprint Analysis in SEEG Source-Space to Identify the Epileptogenic Zone.

ABSTRACT: This case study highlights the application of seizure fingerprint analysis in the source-space of stereo-EEG (SEEG) data to accurately localize the epileptogenic zone (EZ) in patients with complex cortical malformations. A 25-year-old female with extensive bilateral perisylvian polymicrogyria (PMG) presented with intractable focal seizures. The source-level analysis performed in Brainstorm using the sLORETA imaging algorithm subsequently showed EZ fingerprint analysis. The patient underwent MR-guided laser interstitial thermal therapy (LITT), targeting the identified EZ, resulting in postoperative seizure freedom with minimal complications. Extending the analysis from the sensor-space to the source-space could further enhance surgical planning and improve outcomes in complex epilepsy cases

SUBMITTER: Vakilna YS 

PROVIDER: S-EPMC12455889 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature