Human cytomegalovirus-encoded G protein-coupled receptor (GPCR) UL78 regulates viral reactivation.

ABSTRACT: Human cytomegalovirus (CMV) is a ubiquitous pathogen that establishes lifelong, latent infection in hematopoietic cells. Immune-competent individuals are usually asymptomatic for disease. However, immune dysregulation in latently infected individuals can result in viral reactivation, often causing further complications. Viral gene transcription during latency is restricted, although the CMV-encoded G protein-coupled receptor homologs, US28 and UL78, are expressed. We and others find US28 is critical for establishing and maintaining viral latency, in part, through regulating host cell signaling. How US28 switches from pro-latent to pro-lytic during reactivation, however, is unknown, though our findings herein reveal a role for UL78. Myeloid cells infected with a UL78 open reading frame dele

SUBMITTER: Osanyinlusi SA 

PROVIDER: S-EPMC12455920 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature