Paeoniflorin improves atherosclerosis by regulating the gut microbiota and fecal metabolites.

ABSTRACT: Atherosclerosis (AS) is a chronic inflammatory disease and a key factor in cardiovascular disease. Paeoniflorin (PF), a monomer component extracted from red and white paeony roots, has been used for the prevention and treatment of cardiovascular diseases, but the specific mechanism remains unclear. ApoE^-/- mice fed a high-fat diet were randomly divided into a model group, a PF treatment group, a positive control group, and a control group fed a non-high-fat diet. The mice in the PF group were treated with 100 mg/kg (PF-100), 50 mg/kg (PF-50), and 25 mg/kg (PF-25) of PF through gavage. The positive control group was administered 10 mg/kg atorvastatin calcium tablets through gavage. After 8 weeks of gavage, PF delayed the weight gain and reduced the elevated levels of serum total

SUBMITTER: Xia M 

PROVIDER: S-EPMC12455941 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature