Migration and standing variation in vaginal and rectal yeast populations in recurrent vulvovaginal candidiasis.

ABSTRACT: Vulvovaginal candidiasis is a very common human fungal infection. Most are successfully treated with antifungal drugs, yet ~8% lead to recurrent vulvovaginal candidiasis (RVVC). Vaginal and rectal populations have been previously found to be closely related in RVVC. Yet the genomic methods used precluded the assessment of fine-scale relationships and the measurement of within-population variation, a fundamental property with evolutionary implications. To address this gap, we isolated 12 vaginal and 12 rectal yeast isolates from four individuals with a history of RVVC. Three individuals had Candida albicans infections, while the fourth had Nakaseomyces glabratus. All isolates were whole-genome sequenced and phenotyped. Isolates were placed into species-level phylogenies

SUBMITTER: Adamu Bukari A-R 

PROVIDER: S-EPMC12455997 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature