Network controllability analysis reveals the antiviral potential of Etravirine against hepatitis E virus infection.

ABSTRACT: Hepatitis E virus (HEV) is a major cause of acute viral hepatitis in lower- and middle-income countries. HEV infection may lead to acute liver failure, chronic liver disease, and high mortality in pregnant women. Antiviral therapy is not a standard treatment for HEV patients. Computational biology tools promise to revolutionize the antiviral drug discovery. Here, we analyzed the transcriptome data of HEV-infected primary human hepatocyte cells through the connectivity map database and applied control theory on the functional network to identify antiviral targets against HEV. The above analyses predicted PKCβ, PKB/AKT, and CK1ε as potential antiviral targets against HEV. The antiviral function of PKB/AKT and CK1ε was experimentally validated by using respective biochemical inhibitors in g3

SUBMITTER: Ansari S 

PROVIDER: S-EPMC12456023 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature