Association between constipation and risk of cardiovascular or all-cause mortality: a meta-analysis.

ABSTRACT:

Background

Constipation, characterized by infrequent bowel movements or difficulty with defecation, is a common gastrointestinal disorder. This meta-analysis aimed to evaluate the association between constipation and the risks of cardiovascular and all-cause mortality.

Methods

A systematic search of PubMed, Embase and Web of Science was conducted through 6 August 2025, to identify longitudinal observational studies examining the association between constipation and mortality. Pooled adjusted hazard ratios (HR) with 95% confidence intervals (CI) were calculated using random-effects models to account for substantial clinical heterogeneity in constipation definitions across studies.

Results

Thirteen studies (14 articles) involving 3,710,453 participants were included. Po

SUBMITTER: Liu B 

PROVIDER: S-EPMC12456042 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature