Impact of Underlying Portal Hypertension on Severity and Course of Acute-On-Chronic Liver Failure.

ABSTRACT:

Background and aims

The impact of portal hypertension (PH) during acute-on-chronic liver failure (ACLF) remains unclear. This study investigated the link between underlying PH severity, systemic inflammation (SI), and the course of ACLF.

Methods

Consecutive patients with ACLF (n = 192) who met the EASL-CLIF criteria were retrospectively included. PH severity (hepatic venous pressure gradient, HVPG; platelet count, PLT; and other clinical/radiologic PH surrogates) and SI (white blood cell count; C-reactive protein [CRP], interleukin-6) were assessed at the last pre-ACLF visit, ACLF diagnosis (D0), and after 7 (D7), 28 (D28), and 90 (D90) days.

Results

All patients had clinical/radiological signs of PH, and 91 (47%) patients developed ACLF grade 1, 62 (32%) ACLF-2, and

SUBMITTER: Taru V 

PROVIDER: S-EPMC12456108 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature