How admixed captive breeding populations could be rescued using local ancestry information.

ABSTRACT: This paper asks the question: can genomic information be used to recover a species that is already on the pathway to extinction due to genetic swamping from a related and more numerous population? We show that a breeding strategy in a captive breeding program can use whole genome sequencing to identify and remove segments of DNA introgressed through hybridisation. The proposed policy uses a generalized measure of kinship or heterozygosity accounting for local ancestry, that is, whether a specific genetic location was inherited from the target of conservation. We then show that optimizing these measures would minimize undesired ancestry while also controlling kinship and/or heterozygosity, in a simulated breeding population. The process is applied to real data representing the hybridized Sc

SUBMITTER: Lawson DJ 

PROVIDER: S-EPMC12456114 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature