Inadequate immune response to inactivated COVID-19 vaccine among older people living with HIV: a prospective cohort study.

ABSTRACT: The concerns exist regarding the inadequate immune response to inactivated COVID-19 vaccines in some people living with HIV (PLWH). A prospective cohort study was conducted across four regions of Zhejiang, China. Both PLWH and healthy controls (HCs) received two doses of the inactivated COVID-19 vaccine. Adverse reactions within 7 days after each injection were monitored. PLWH with CD4 counts <500 cells/µL received a third dose. Neutralizing antibodies (NAbs) and IgG were measured to evaluate the immunogenicity of each dose. A total of 400 PLWH were enrolled, with 12.2% aged ≥60 years. Adverse reactions to the first two doses were mild or moderate in PLWH (12.0% and 5.5%). After the second dose, the geometric mean titer (GMT) of NAbs was lower in PLWH (46.9, 95% confidence interval [CI] 43

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12456149 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature