Preoperative Enterosignatures Predict Surgical Site Infections After Abdominal Surgery.

ABSTRACT:

Background

The relationship between preoperative intestinal microbiota composition and the development of surgical site infections (SSIs) following abdominal surgery is not well understood. The aim of this study was to characterize the preoperative rectal microbiota using the novel concept of enterosignatures (ESs) in patients undergoing abdominal surgery and assess their association with SSIs.

Methods

In this prospective cohort study, preoperative rectal microbiota from 133 patients undergoing elective abdominal surgery was profiled using 16S rRNA sequencing. ESs were calculated using high-quality genus-level taxonomy, simplifying complex microbial compositions into 5 generalizable patterns: Bacteroides-, Firmicutes-, Prevotella-, Bifidobacterium-, or Escherichia<

SUBMITTER: Zwicky SN 

PROVIDER: S-EPMC12456171 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature