Exploratory cluster analysis of IL2Ra and associated biomarkers and complications after blunt chest trauma.

ABSTRACT:

Background

Rib fractures compromise approximately 40% of all fractures in the United States. Despite their prevalence, the relationship between rib fractures, solid organ injuries, and immune responses remains poorly understood. This exploratory study investigates the immunological profile associated with pulmonary and renal complications in rib fracture patients using data from our Surgical Critical Care Initiative Clinical Data Repository. The aim is to correlate distinct cytokine/chemokine profiles with high-energy rib fracture patterns, such as first rib fracture, and associated complications, potentially providing predictive biomarkers for patient outcomes.

Methods

Clinical and demographic data on patients with rib fractures were extracted from Surgical Critical Care In

SUBMITTER: Haines KL 

PROVIDER: S-EPMC12456203 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature