Hypoxia increases susceptibility of human intestinal epithelial cells to rotavirus infection through repression of interferon induction.

ABSTRACT: Intestinal epithelial cells (IECs) serve as both a physical barrier and a source of robust antiviral interferon (IFN) response. As such, they constitute the primary barrier that enteric viruses, such as rotavirus, need to overcome to initiate infection. The gut is characterized by very low oxygen levels (hypoxia) within the lumen, resulting in a unique hypoxic physiological environment in which rotavirus infection occurs. Depending on the tissues or viruses, conflicting results have been described for the role of hypoxia in regulating viral infections, where hypoxia could have either a proviral or antiviral function. Since intestinal epithelial cells naturally exist in a hypoxic environment, it is essential to investigate how these conditions affect rotavirus infection. We found that hypox

SUBMITTER: Jacobs SO 

PROVIDER: S-EPMC12456215 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature