An Approach to Integrate Metagenomics, Metatranscriptomics and Metaproteomics Data in Public Data Resources.

ABSTRACT: The availability of public metaproteomics, metagenomics and metatranscriptomics data in public resources such as MGnify (for metagenomics/metatranscriptomics) and the PRIDE database (for metaproteomics), continues to increase. When these omics techniques are applied to the same samples, their integration offers new opportunities to understand the structure (metagenome) and functional expression (metatranscriptome and metaproteome) of the microbiome. Here, we describe a pilot study aimed at integrating public multi-meta-omics datasets from studies based on human gut and marine hatchery samples. Reference search databases (search DBs) were built using assembled metagenomic (and metatranscriptomic, where available) sequence data followed by de novo gene calling, using both data from the same

SUBMITTER: Wang S 

PROVIDER: S-EPMC12456259 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature