Ionic-Liquid-Modified Nanoparticles as Potential Mucus Modulators for Nasal Drug Delivery.

ABSTRACT: Mucosal barriers are a natural defense system for preventing the entry of foreign objects into the body; however, they pose obstacles for effective drug delivery. Coated polymer nanoparticles (NPs) have been shown to possess improved rates of diffusion across mucus compared to their uncoated, or bare, counterparts. Choline carboxylic acid-based ionic liquids (ILs) are highly tunable and show high biocompatibility and mucus modulation properties, making them an ideal choice for the improvement of NP diffusion through mucosal barriers. This study aimed to investigate whether the use of choline-based ILs has a positive effect on the dispersibility of poly(lactic-co-glycolic acid) (PLGA), poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) (PEG-PLGA), and p

SUBMITTER: VanLandingham ME 

PROVIDER: S-EPMC12456362 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature