A simulation study on the role of mitochondria-sarcoplasmic reticulum Ca²⁺ interaction in cardiomyocyte energetics during exercise.

ABSTRACT: Previous studies demonstrated that the mitochondrial Ca²⁺ uniporter MCU and the Na⁺-Ca²⁺ exchanger NCLX exist in proximity to the sarcoplasmic reticulum (SR) ryanodine receptor RyR and the Ca²⁺ pump SERCA, respectively, creating a mitochondria-SR Ca²⁺ interaction. However, the physiological relevance of the mitochondria-SR Ca²⁺ interaction has remained unsolved. Furthermore, although mitochondrial Ca²⁺ has been proposed to be an important factor regulating mitochondrial energy metabolism, by activating NADH-producing dehydrogenases, the contribution of the Ca²⁺-dependent regulatory mechanisms to cellular functions under physiological conditions has been controversial. In this study, we constructed a new

SUBMITTER: Takeuchi A 

PROVIDER: S-EPMC12456394 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature