Effect of combined transcranial direct current stimulation and cognitive training on brain microstructure and network homogeneity in late-life depression: a pilot study.

ABSTRACT:

Background

Depression and cognitive decline frequently coexist in older individuals. However, effective treatment options remain limited. Neuromodulation has shown potential beyond traditional cognitive training; however, its specific effects on brain connectivity and white matter structures remain unclear. The purpose of this study was to evaluate the effects of combining transcranial direct current stimulation (tDCS) with cognitive training on white matter microstructure integrity and default mode network (DMN) homogeneity in older adults with cognitive deficits and depressive symptoms.

Methods

This double-blind, randomized sham-controlled study compared cognitive training combined with either anodal or sham tDCS in older adults with late-life depression and cognitive decl

SUBMITTER: Ha J 

PROVIDER: S-EPMC12456841 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature