Depth-resolved fiber photometry of amyloid plaque signals in freely behaving Alzheimer's disease mice.

ABSTRACT:

Significance

Current preclinical evaluation of Alzheimer's disease pathology in mouse models relies on post-mortem analyses, which hinders the development and optimization of therapeutic approaches. Although in vivo methods exist, monitoring amyloid plaque signals across multiple brain regions in freely behaving animals remains a significant challenge.

Aim

We aim to develop an optical approach to address this challenge.

Approach

We used flat and tapered optical fibers in an Alzheimer's mouse model.

Results

We first confirmed that conventional flat fiber-based photometry can detect amyloid plaque signals across multiple brain regions under anesthesia after injecting a blood-brain-barrier-permeable tracer, Methoxy-X04. The depth profile of in vivo f

SUBMITTER: Byron N 

PROVIDER: S-EPMC12456868 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature