CD4+ T-lymphocytes in human saccular intracranial aneurysm walls are associated with aneurysm rupture.

ABSTRACT: Chronic inflammation in saccular intracranial aneurysm (sIA) walls is associated with wall rupture. Previous studies have shown an association between macrophages and CD3+ T-lymphocytes with sIA wall degeneration and rupture but the roles of T-lymphocyte subtypes and B-lymphocytes are poorly understood. Here, cyclic multiplexed immunofluorescent staining was used to investigate the presence of T-lymphocytes helper CD4+ and cytotoxic CD8+ T-lymphocytes and CD20+ B-lymphocytes in 16 unruptured and 20 ruptured sIA walls. The sIA walls contained both CD4+ (n = 25/35) and CD8+ (n = 21/35) subtypes. There was a greater density of CD4+ T-lymphocytes (median 7, range 0-642 cells/mm2) vs CD8+ T-lymphocytes (median 1, range 0-30 cells/mm2). The density of CD4+ T-lymphocytes was associated with wall

SUBMITTER: Firtser N 

PROVIDER: S-EPMC12456882 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature