Clinicopathological characterization of enteric glia in colorectal cancer: Insights from a population-based cohort.

ABSTRACT: Enteric glia contribute to the regulation of mucosal homeostasis and intestinal immunity. Enteric glia dysfunction is linked to various gastrointestinal disorders. We aimed to characterize the phenotype of enteric glia in colorectal cancer (CRC) and examine their association with CRC patient characteristics. Healthy, adenoma, and tumor tissues from CRC patients were immunohistochemically stained for the glial markers S100B and glial fibrillary acidic protein (GFAP). GFAP-positive enteric glia were identified within carcinoma tissue stroma but were absent in normal mucosa or adenoma tissue from the same patients. S100B staining was detected in all sample types. Two CRC patient cohorts (n = 447 and n = 324) were analyzed for GFAP staining and to assess association of GFAP immunoreactivity wi

SUBMITTER: Thijssen MS 

PROVIDER: S-EPMC12456883 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature