Motion-Insensitive Flip Angle Modulated Liver Proton Density Fat-Fraction and R2* Mapping During Free-Breathing MRI in a Clinical Setting.

ABSTRACT:

Background

Breath-held quantitative three-dimensional chemical-shift-encoded (3D-CSE)-MRI is widely used for liver fat and iron quantification but is limited in patients unable to hold breath. Motion-insensitive two-dimensional flip angle modulated (2D-FAM) acquisitions with short temporal aperture may address this limitation.

Purpose

To evaluate the performance of 2D-FAM-based CSE-MRI during free-breathing for quantifying proton density fat-fraction (PDFF) and R2*-based liver iron concentration (LIC).

Study type

Retrospective single-center observational analysis.

Population

230 patients (110 women [47.8%], mean age 51 ± 16 years [standard deviation, SD], range 4-85), undergoing routine clinical care between January and August 2024.

Field strength/sequence</

SUBMITTER: Heidenreich JF 

PROVIDER: S-EPMC12456944 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature