Multiphase separation in postsynaptic density regulated by membrane geometry via interaction valency and volume.

ABSTRACT: Biomolecular condensates are found at various cellular locations, nucleus, cytoplasm, and membrane. These condensates often contain multiple components and can separate into multiple phases with various morphologies such as core-shell droplets, implicating functional roles. Demixing and arrangements of condensates are determined by competitive interactions and their locations. Recent studies reported a puzzling multiphase morphology in postsynaptic density components: AMPA receptor, NMDA receptor, PSD-95, and CaMKII. The multiphase morphology appears reversed when transitioning from the solution to the membrane. Using this system as a model, we study the multiphase behavior of condensates in solution (3D) and domain formation on and beneath the membrane (2D) and elucidate molecular mechani

SUBMITTER: Yamada R 

PROVIDER: S-EPMC12456954 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature