Mathematical model of tumor-macrophage dynamics in glioma to advance myeloid-targeted therapies.

ABSTRACT: Recent biological research has highlighted the relevance of myeloid-cell populations in glioma growth, with a particular role played by tumor-associated macrophages (TAMs), which comprise resident microglia and monocyte-derived macrophages. Additionally, radiation therapy, the most common treatment for gliomas, significantly alters the tumor microenvironment, affecting TAMs and contributing to tumor recurrence. Promising preclinical studies have identified and developed drugs targeting TAMs. The development and combined deployment of these therapies require in silico techniques that enable us to optimize their outcomes. To do so, we need mathematical models of glioma growth and therapy response that explicitly incorporate TAMs-an often overlooked component in existing models. Here, we pres

SUBMITTER: Bosque JJ 

PROVIDER: S-EPMC12457100 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature