Analyzing the impact of human leukocyte antigen mismatch on the incidence of prostate cancer and the advantage of T cell therapy in patients after kidney transplantation based on the United Network for Organ Sharing database.

ABSTRACT:

Background

We aim to analysis the impact of Human Leukocyte Antigen (HLA) mismatch between kidney transplant donors and recipients on the incidence of prostate cancer after kidney transplantation (KT). Meanwhile, understanding the use of T cell therapy is of great importance after kidney transplantation from the perspective of prostate cancer occurrence.

Methods

A retrospective study was conducted on kidney transplant recipients based on the United Network for Organ Sharing (UNOS) database from 2000 to 2019. General demographic data, socio-economic and educational data, personal medical history, immunosuppressive therapy regimens, and HLA typing of donors and recipients were collected to analyze the impact of: (1) baseline patient characteristics; (2) HLA mismatch; and (3) H

SUBMITTER: Gao Y 

PROVIDER: S-EPMC12457105 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature