Diphenyl pyridine intervention improves <i>S. aureus</i>-induced pneumonia by globally regulating transcriptome profile.

ABSTRACT:

Background

Pneumonia, induced by various bacteria or viruses, is a globally prevalent inflammatory disease that threatens the life of millions of people. Staphylococcus aureus (S. aureus) is a major pathogen of pneumonia and can be inhibited by Diphenyl pyrimidine (DP), while the underlying mechanisms are largely unknown.

Methods

In this study, we conducted the S. aureus-induced rat pneumonia model and then performed DP treatment to inhibit the injury. Meanwhile, whole transcriptome sequencing (RNA-seq) experiment was performed to identify the dysregulated genes with expression and alternative splicing changes, as well as their enriched functions. Hub genes and immune cell proportion changes by DP were also identified to explore the underlying mechanism.

SUBMITTER: Duan W 

PROVIDER: S-EPMC12457106 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature