Novel diagnostic biomarkers associated with macrophage-microglia in spinal cord injury.

ABSTRACT:

Background

Spinal cord injury (SCI) is a devastating disorder featuring serious motor dysfunction and proprioceptive deficits due to central nervous system (CNS) damage. During its progression, macrophage-microglia (MM) cells are rapidly activated and play pivotal roles in the inflammatory response through various mechanisms. However, limited research has investigated the differential gene expression between the two groups before and after injury, and these important genes may therefore serve as potential biological diagnostic markers.

Methods

Our study utilized the Gene Expression Omnibus (GEO) data for SCI-related MDEG identification. Key hub genes were screened using multiple machine learning(ML) algorithms. Their predictive potential was subsequently validated using inde

SUBMITTER: Zheng M 

PROVIDER: S-EPMC12457113 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature