Gan-du-qing attenuates PM_2.5-induced Chronic Airway Inflammation via regulating the pulmonary microbiota and metabolic profiles.

ABSTRACT:

Background

Substantial evidence links fine particulate matter (PM_2.5) to the development of inflammatory lung diseases such as chronic airways, but effective treatments are lacking. Gan-du-qing (GDQ) Decoction is a traditional Chinese medicine formula for chronic airway inflammation. However, whether GDQ can ameliorate PM_2.5-induced lung injury and its mechanism are unknown, and we will further investigate.

Study design/methods

Male Sprague-Dawley (SD) rats weighing 120 grams were utilized to establish a rat model of lung injury through systemic exposure to PM_2.5. We built a real environmental exposure chamber with an exposure period of 16 weeks and the average concentration exposed was 110.5 μg/mł. The exposure chamber is located at 12 Bridg

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12457115 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature